Let the competent team of scientists at MMSD streamline your analysis and product development.

Molecular MS Diagnostics is an emerging analytical/bioanalytical laboratory providing a variety of testing and product development services. We offer pharmaceutical sample analyses to meet the needs of your company in an efficient and cost-effective manner.

Assays, developed at the pre-clinical stage, can be the cohesive force in integrating a product development program from pre-clinical to early clinical through proof-of-concept studies—and beyond. The scientists at MMSD have had exposure to a wide variety of product development and assay applications. We are well positioned to offer guidance on product development and assay technology limitations.

Services Available

Analytical Services:
  • Assay and impurity HPLC testing for drug substance, drug products
  • Method development, verification/validation, method transfer
  • Dissolution Testing
Bioanalytical Services:
  • Plasma/blood stability assays
  • Plasma and urine analysis of generic drugs and NCE's
  • LC-MS/MS method development, verification/validation, method transfer
Strategic Product Development:
  • Accurate knowledge of unmet need in the product market
  • Beneficial planning and management of product development
  • Effective management of resources and tools

Sample Prep Tips

These tricks and tips will save time and trouble further downstream:

  • Never heat frozen plasma in a water bath to hasten thawing, as this will cause unwanted protein precipitation. Allow it to thaw out at room temperature, just plan ahead.
  • When investigation drug-in-plasma stability, be sure to perform at least three freeze cycles, otherwise you may find unexpected surprises caused by drug solubility and/or matrix instability. Be diligent in this step during method development.
  • To solve carryover problems, always chose a wash solvent/solvents most soluble for your analyte. The best approach is to wash with the most soluble, non-polar solvent, followed by the most soluble polar (aqueous) solvent. Differences in pH can have a dramatic effect on analyte solubility, so chose the pH of your polar solvent wisely.

Method development tips

Maximize efficiency with these simple method development tips...

  • Don't reinvent the wheel! Do some research to see what others have already developed. This will provide a proven base to develop your method fast.
  • Know what your analyte is soluble in and how it may behave with changes in pH. And never assume it is soluble in a typical nonpolar solvent. The solubility should also be determined through testing.
  • A thorough understanding of detectors and their various settings will aid in choosing which system will work best with your particular analyte.Switching to a more selective wavelength can help reveal what may be co-eluting or increase selectivity.
  • After demonstrating precision and accuracy, be sure to perform an analyte degradation analysis to establish stability indicators as early as possible.

News & Events

MMSD is now ISO9001-2008 Certified

Molecular MS Diagnostics, LLC. achieves effective collaboration with Ocular Therapeutix, Inc., leading to completion of a successful Proof of Principle Clinical Study
Ocular Therapeutix, Inc., (OCUTX) has announced the completion of a successful proof of Principle Clinical Study with their novel, sustained delivery Moxifloxacin punctum plug . Molecular MS Diagnostics,LLC., collaborated with OCUTX in their effecive drug delivery research in the areas of drug release, analytical, bio-analytical, pK studies.

Additional information is available at the press release at www.ocutx.com

MMSD celebrates 2-Year anniversary
(Press Release)

MMSD opens analytical and bioanalytical testing facility in Cranston, RI in May of 2007